CD24, also known as thermostable antigen or small cell lung cancer cluster 4 antigen, is a highly glycosylated glycosylphosphatidylinositol-anchored cell surface protein. CD24 interacts with Siglec-10 molecules on innate immune cells to transmit immunosuppressive signals to suppress inflammation. Studies have shown that CD24 is expressed in several solid tumors. This product is a CD24-FC recombinant protein (the FC tag can be removed by enterokinase), which can be used for monoclonal antibody screening or antibody function verification.

Product name: Recombinant human CD 24 protein

Species: Human origin

Gene sequence number:P25063

Tags: Human-Fc Tag

Tag site: C terminal

Restriction site: enterokinase

Expression area: extracellular segment 27-59AA

Host cell:CHO

Purity: ＞90%

Purification method: Protein A column

Preservation system: PBS+20% glycerol

Storage conditions: -80℃

Illustration:Lane M on the left is the protein MW marker, Lane 1 is 15ug CD24(27-59 )-Fc protein;

The picture on the right shows the FACS detection of CD24-Fc protein binding to 293T overexpressing CD24-CAR

Reference materials:

1. CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system

2. Antibody-based targeting of CD24 enhances antitumor effect of cetuximab via attenuating phosphorylation of Src/STAT3

3. Involvement of CD24 in Multiple Cancer Related Pathways Makes It an Interesting New Target for Cancer Therapy